Brown University Epidemiologist Edmond Shenassa first uncovered the link between mold exposure and clinical depression in 2007. His study was the largest at the time in examination of the correlates between mold and mental state(s) of the ~6,000 subjects. Interestingly, Shanassa first set out on this investigation with the ultimate goal of debunking earlier literature that suggested a link between mold and depression. This groundbreaking study opened Pandora's Box for scientists studying depression, since statistically speaking moving forward, controls for household mold would be a staple in any future studies.Mold's mycotoxins have historically been known for 'impeding function of the frontal cortex' the control center for behavior, socialization, problem solving and memory. Mycotoxicity has also been linked to a host of neurological infections including fungal meningitis. Interrupting neural circuitry that is essential in everyday activity can certainly result in behavior significant of DSM criterion for clinical depression, however the precise function of mycotoxin exposure and how it interrupts specific neural processes has yet to be uncovered.